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pentobarbital decreases amounts of toremifene by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. CYP3A4 inducers improve fee of toremifene metabolism, lowering the continuous-condition focus in serum.pentobarbital will lessen the extent or result of levamlodipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism